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Antibacterial Surface And Method Of Fabrication

总结

This Invention Involves A Plasma Treated And Controllable Release Antimicrobial Peptide Coated Titanium Alloy For Surgical Implantation, Where The Alloy With Antimicrobial Properties Is Fabricated Using Surface Techniques Without Adversely Compromising Its Biocompatibility And Original Mechanical Properties. The Surface Techniques Form Antimicrobial Layers On The Alloy Capable Of Resisting Microbial Adhesion And Proliferation, While Allowing Mammalian Cell Adhesion And Proliferation When The Alloy Is Implanted To Human Body. In One Embodiment, Piii&D Is Applied To Incorporate Ions, Electrons, Free Radicals, Atoms Or Molecules On A Titanium Alloy Substrate. A Pressurized Hydrothermal Treatment Can Be Carried Out To Establish Reactive Functional Groups For Antimicrobial Purpose Or For Connecting The Substrate And External Antimicrobial Molecules. An Outermost Layer Of The Titanium Alloy Includes Antibacterial Peptides Possessing A Controllable Release Mechanism, And Is Fabricated Alone Or In An Assembly Of The Aforementioned Basal Surface Layers. The Controllable Release Mechanism Is Able To Withstand Long-Term Deep Tissue Infection After Surgery, And In An Embodiment Comprises Aptes As A Linker Molecule.

附加资料

Patent Number: US20110046747A1
Application Number: US2010706483A
Inventor: Yeung, Kelvin Wai Kwok | Cheung, Kenneth Man Chee | Luk, Keith Dip Kei | Yeung, Che Yan | Kao, Richard Yi Tsun | Chu, Paul Kim Ho
Priority Date: 19 Feb 2009
Priority Number: US20110046747A1
Application Date: 16 Feb 2010
Publication Date: 24 Feb 2011
IPC Current: A61F000228
US Class: 6230236
Title: ANTIBACTERIAL SURFACE AND METHOD OF FABRICATION
Usefulness: ANTIBACTERIAL SURFACE AND METHOD OF FABRICATION
Summary: For controlling antimicrobial and biocompatible titanium alloys for reducing post-operative implant-related bacterial infections.

主要类别

生物医学

细分类别

医疗植入

申请号码

US2010706483A

国家/地区

香港