Lysosomal Storage diseases (LSD) are inherited genetic defects, resulting in an enzyme deficiency.This deficiency prevents the lysosome from metabolizing cellular waste, and results in their accumulation in the cell. Excessive storage of proteins, saccharides and/or fats can cause permanent cellular.....
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Need:There is a need for novel compounds with anti-biofilm activity to increase susceptibility of certain bacterial strains towards conventional antibiotics. Innovation:We have developed novel compounds with anti-biofilm activity. We are proposing to use our compounds as a potential anti-biofilm str.....
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ER stress, elicited by chemotherapeutic agents such as doxorubicin, 5FU, vincristine and bortezomib, or statins such simvastatin, triggers cell death at least in part through generation of leukotriene C4 (LTC4), which induces ROS accumulation, DNA damage and subsequent cell death. LTC4 can be produc.....
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Animal models of human diseases of the CNS occupy a central role in drug discovery yet these models fail to yield new insights and efficacious drugs for the treatment of these diseases, in a field having a collective economic cost of over $40 billion per year. The number of CNS drugs reaching approv.....
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