Novel Human Virus Causing Respiratory Tract Infection And Uses Thereof
The Present Invention Provides The Complete Genomic Sequence Of A Novel Human Coronavirus, Coined As Coronavirus-Hku1 ("Cov-Hku1"), Isolated In Hong Kong From A Patient Who Had A Recent History Of Visit To Schenzhen. China. The Virus Belongs To The Order Nidovirales Of The Family Coronavirdae, Being A Single-Stranded Rna Virus Of Positive Polarity. The Invention Also Provides The Deduced Amino Acid Sequences Of The Complete Genome Of The Cov-Hku1. The Nucleotide Sequences And Deduced Amino Acid Sequences Of The Cov-Hku1 Are Useful In Preventing, Diagnosing And/Or Treating The Infection By Cov-Hku1. Furthermore, The Invention Provides Immunogenic And Vaccine Preparations Using Recombinant And Chimeric Forms As Well As Subunits Of The Cov-Hku1 Based On The Nucleotide Sequences And Deduced Amino Acid Sequences Of The Cov-Hku1.
Inventor: Yuen, Kwok Yung | Woo, Chiu Yat Patrick | Lau, Kar Pui Susanna | Chan, Kwok Hung | Poon, Lit Man | Peiris, Joseph Sriyal Malik | Guan, Yi
Priority Number: US7553944B2
IPC Current: C07H002102 | A61K003900 | A61K003912 | C12N001500
US Class: 5360231 | 4241851 | 4353201 | 514044R | 5301851 | 5301861
Assignee Applicant: The University of Hong Kong
Title: Human virus causing respiratory tract infection and uses thereof
Usefulness: Human virus causing respiratory tract infection and uses thereof
Summary: The sequences, composition, vaccine, and method are useful for preventing, diagnosing, and/or treating infection caused by CoV-HKU1, e.g. respiratory tract infection.
Novelty: New nucleic acid molecule encoding human virus, useful for preventing, diagnosing, and/or treating infection caused by coronavirus-HKU1, e.g. respiratory tract infection
生物医学
病原
香港
