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Preventive or therapeutic agent for cerebral ischemic injury or cerebral ischemia reperfusion in stroke

Summary

The present invention provides a preventive or therapeutic agent for cerebral ischemic injury or cerebral ischemic reperfusion injury in stroke such as cerebral infarction and cerebral hemorrhage which exerts its effect through a different mechanism from that of conventional therapeutic agents and can be taken for a long period. The present invention is a preventive or therapeutic agent for cerebral ischemic injury or cerebral ischemic reperfusion injury in stroke which contains 6-fluoro-2',5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxamide as an active ingredient. A particularly preferable compound is an optically resolved (2S,4S)-form of fidarestat.

Supplementary Information

Patent Number: US20090076105A1
Application Number: US2008195084A
Inventor: CHUNG, Sookja Kim | CHUNG, Stephen | HIBI, Chihiro
Priority Date: 20 Feb 2006
Priority Number: US20090076105A1
Application Date: 20 Aug 2008
Publication Date: 19 Mar 2009
IPC Current: A61K00314188 | A61P000910
US Class: 514393
Assignee Applicant: Sanwa Kagaku Kenkyusho Co. Ltd.
Title: PREVENTIVE OR THERAPEUTIC AGENT FOR CEREBRAL ISCHEMIC INJURY OR CEREBRAL ISCHEMIA REPERFUSION IN STROKE
Usefulness: PREVENTIVE OR THERAPEUTIC AGENT FOR CEREBRAL ISCHEMIC INJURY OR CEREBRAL ISCHEMIA REPERFUSION IN STROKE
Summary: The method is useful for preventing or treating cerebral ischemic injury or cerebral ischemic reperfusion injury in stroke, which is cerebral infarction, cerebral hemorrhage, subarachnoid hemorrhage or transient cerebral ischemia, where the cerebral ischemic injury or cerebral ischemic reperfusion injury is caused by: thrombolytic therapy for acute ischemic stroke; surgical intervention, which is hematoma evacuation, hematoma aspiration or ventricular drainage; a procedure of carotid artery stent placement, bypass operation, cervical carotid endarterectomy for cervical carotid artery occlusion or stenotic or obstructive lesion of an intracranial main artery (all claimed). Tests details are described but no results given.
Novelty: Preventing or treating cerebral ischemic injury or cerebral ischemic reperfusion injury in stroke e.g. cerebral infarction in patient, comprises administering 6-fluoro-2',5'-dioxospiro(chroman-4,4'-imidazolidine)-2-carboxamide

Industry

Biomedical

Sub Category

Medical Composition

Application No.

US2008195084A

Country/Region

Hong Kong