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Genetically Modified Plants Comprising Sars-Cov Viral Nucleotide Sequences And Methods Of Use Thereof For Immunization Against Sars

Summary

The Invention Relates To Genetically Modified Plants And Progeny Thereof Which Constitute Edible Plant-Derived Mucosal Vaccines And Injectable Plant-Derived Mucosal Vaccines Against Severe Acute Respiratory Syndrome (Sars). The Invention Relates To A Recombinant Vector That Transforms Specifically, But Not Limited To, The Nuclei And/Or Plastids Of Tobacco, Tomato And Lettuce Plants For Antigen Production. In Specific Embodiments, The Plastid Transformation Vector Expressing The Nucleotide Sequences Are Pcv1, Pcv6 And Pcv8, And Their Derivatives Containing An S1 With Nucleotide (But Not Amino Acid) Changes To Optimize Codon Usage For Expression In Plants. The Present Invention Relates To Methods Of Making The Modified Plants Which Comprises Transformation Of Plants With Vectors For Nuclear Expression And/Or Plastid Expression Of Nucleotide Sequences Of The Sars-Cov Virus, Fragments, Derivatives, Analogs, Or Variants Thereof. The Present Invention Also Relates To Methods Of Immunization Against Sars And Methods Of Antibody Detection Using The Sars-Cov Antigens Generated By The Plastid And/Or Nuclear Vector(S) Transformed Plants.

Supplementary Information

Patent Number: US20060053516A1
Application Number: US20044399A
Inventor: Chye, Mee | Li, Hong | Ramalingam, Sathiskumar | Poon, Leo | Peiris, Joseph
Priority Date: 5 Dec 2003
Priority Number: US20060053516A1
Application Date: 3 Dec 2004
Publication Date: 9 Mar 2006
IPC Current: A61K003912 | A01H000100 | A61K00317088 | A61K003618 | A61K0039215 | C12N000504 | C12N001582
US Class: 800288 | 4241861 | 435419 | 435468
Assignee Applicant: The University of Hong Kong
Title: Genetically modified plants comprising SARS-CoV viral nucleotide sequences and methods of use thereof for immunization against SARS
Usefulness: Genetically modified plants comprising SARS-CoV viral nucleotide sequences and methods of use thereof for immunization against SARS
Summary: The vector and plant are useful for immunization of a subject against severe acute respiratory syndrome (SARS). The subject is preferably a human. (M3) is useful for detecting an antibody to a SARS-CoV viral antigen in a sample. The sample is preferably a biological fluid such as blood, serum, plasma, saliva, urine, stool, sputum, nasopharyngeal aspirates, cells or tissues. (All claimed).

Industry

Biomedical

Sub Category

Pathogen

Application No.

US20044399A

Country/Region

Hong Kong