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Inhibitors of Phospholipase D as a therapeutic against Alzheimer's Disease

Summary
Gilbert Di Paolo Ph.D.
Technology Benefits
Targets amyloid plaque buildup instead of treating symptomsTherapeutic approach distinct from existing market optionsProven efficacy in vivo animal modelsPatent information:Patent Pending [WO2008064244 A2] (http://patentscope.wipo.int/search/en/WO2008064244)Tech Ventures Reference: IR 2583
Technology Application
Treatment for Alzheimer’s DiseaseResearch tool for elucidating Alzheimer’s disease pathogenesisDevelopment of diagnostics utilizing PLD activity
Detailed Technology Description
Gilbert Di Paolo Ph.D.
*Abstract
None
*Inquiry
Jerry KokoshkaColumbia Technology VenturesTel: (212) 854-8444Email: TechTransfer@columbia.edu
*IR
2583
*Principal Investigator
*Publications
Oliveira TG, Chan RB, Tian H, Laredo M, Shui G, Staniszewski A, Zhang H, Wang L, Kim TW, Duff KE, Wenk MR, Arancio O, Di Paolo G. Phospholipase d2 ablation ameliorates Alzheimer’s disease-linked synaptic dysfunction and cognitive deficits.. J Neurosci. 2010 Dec 8;30(49):16419-28.
Country/Region
USA

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